In 1971, Ladd joined the cast of the CBS soap opera, The Secret Storm. She was the second actress to play the role of Kitty Styles on the long-running daytime serial. She later had a supporting role in Roman Polanski's 1974 film Chinatown, and was nominated for an Academy Award for Best Actress in a Supporting Role for her role as Flo in the film Alice Doesn't Live Here Anymore. That film inspired the TV series Alice, in which Flo was portrayed by Polly Holliday. When Holliday left the TV series, Ladd succeeded her as waitress Isabelle "Belle" Dupree. In 1993, Ladd appeared in the episode "Guess Who's Coming to Chow?" of the CBS comedy/western series Harts of the West in the role of the mother of co-star Harley Jane Kozak. The 15-episode program, set on a dude ranch in Nevada starred Beau Bridges and Lloyd Bridges.
In 2004, Ladd played psychic Mrs. Druse in the television miniseries of Stephen King's Kingdom Hospital. In April 2006, Ladd released her first book entitled: Spiraling Through The School Of Life: A Mental, Physical, and Spiritual Discovery. In 2007, she co-starred in the Lifetime Television film Montana Sky.
In addition to her Academy Award nomination for Alice Doesn't Live Here Anymore, she was also nominated (again in the Best Actress in a Supporting Role category) for both Wild at Heart and Rambling Rose, both of which she starred alongside her daughter Laura Dern. Dern received a nomination for Best Actress for Rambling Rose. The dual mother and daughter nominations for Ladd and Dern in Rambling Rose marked the first time in Academy Award history that such an event had occurred. They were also nominated for dual Golden Globe Awards in the same year.
Ladd has worked in the theatre as well. She made her Broadway debut in the play Carry Me Back to Morningside Heights in 1968. In 1976 she starred in the play, A Texas Trilogy: Lu Ann Hampton Laverty Oberlander, for which she received a Drama Desk Award nomination.
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